Event Date: Tuesday, August 2, 2016
Professor Stefan France
School of Chemistry & Biochemistry
Georgia Institute of Technology
Atlanta, Georgia
will present a talk entitled:
The Catalytic, Formal Homo-Nazarov Cyclization: A Promising Template for Diversity-Oriented Synthesis
on Tuesday, August 2, 2016
at 2:30 PM
Room ChB 115, Chemistry Building
Abstract:
A critical challenge in the field of organic synthesis is assembling large collections of diverse compounds for use as chemical building blocks, biological probes, therapeutics or organic materials. Since the formal characterization of diversity-oriented synthesis (DOS), identification of effective examples of DOS remains an important endeavor for synthetic and pharmaceutical chemists, requiring new strategies to generate broader skeletal diversity. Over the last decade, the formal homo-Nazarov cyclization has been an increasingly popular strategy for the concise assembly of functionalized six-membered rings due to the advent of catalytic methods to promote the transformation under milder reaction conditions. In this seminar, the strategic use of the formal homo-Nazarov cyclization as a mechanistic template, with specific emphasis towards diversity-oriented synthesis, will be discussed. Examples of the utility of the method toward accessing both chemical and skeletal diversity will be highlighted, including recent progress toward the total synthesis of propolisbenzofuran B, a complex natural product with interesting anti-cancer properties.
Refreshments will be served 10 minutes prior to talk